effects of hydroalcoholic extract of tanacetum sonbolii (asteraceae) on pain-related behaviors during formalin test in mice

نویسندگان

mohammad sofiabadi cellular and molecular research center, qazvin university of medical sciences, qazvin, iran.

hassan azhdari zarmehri department of basic sciences, torbat heydariyeh university of medical sciences, torbat heydariyeh, iran.

firiozeh naderi cellular and molecular research center, qazvin university of medical sciences, qazvin, iran.

mohhadese ghalandri physiology–pharmacology research center, rafsanjan university of medical sciences, rafsanjan, iran.

چکیده

introduction: tanacetum sonbolii (asteraceae) is an endemic species in iran. in the present study, we examined the effects of tanacetum sonbolii hydroalcoholic extract on the formalin test in mice. methods: 126 swiss albino mice weighing 230-280g were used as subjects. the formalin test was performed on two control groups (marked as intact and saline groups n = 6 in each group) and an experimental group. in all groups, the formalin test was recorded for 60 min after administration of extract and drugs in mice. results: the results showed that tanacetum sonbolii (150 and 300 mg/kg) produced significant antinociception in phase 2. in addition, different doses of tanacetum sonbolii extract (600, 900 and 1200 mg/kg) also induced antinociceptive effects in phase1 and phase 2. on the other hand, morphine could induce antinociception in a dose-dependent manner. diclofenac (10 mg/kg) failed to affect the pain scores compared to tanacetum sonbolii (300 mg/kg) group. discussion: it seems that administration of hydroalcoholic extract of tanacetum sonbolii has the potential to relieve pain through both central and peripheral mechanisms in persistent inflammatory nociception.

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Effects of Hydroalcoholic Extract of Tanacetum Sonbolii (Asteraceae) on Pain-related Behaviors during Formalin Test in Mice

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عنوان ژورنال:
basic and clinical neuroscience

جلد ۵، شماره ۲، صفحات ۱۶۲-۱۶۸

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